新文章：研究：伊维菌素在类风湿关节炎中的应用 - 巴基斯坦2023年论文
伊维菌素与类风湿关节炎有什么关系？
2023年Khan等人 - 评估伊维菌素对完全弗氏佐剂诱导的大鼠关节炎治疗潜力的研究：涉及炎症介质的作用
要点：
32只雄性Wistar大鼠被随机分为四组：对照组、疾病组、地塞米松组和伊维菌素组
在类风湿关节炎诱导7天后，动物接受地塞米松（类固醇）5 mg/kg和伊维菌素6 mg/kg的治疗
结果：
伊维菌素对大鼠体重无显著影响。疾病组大鼠体重下降。
在研究第15天，地塞米松组和伊维菌素组的关节炎症状与疾病组相比显著减少
疾病组白细胞计数显著增加
治疗后，地塞米松组和伊维菌素组的白细胞计数显著降低
与对照组相比，疾病组出现高度显著的皮下炎症、滑膜炎症和骨侵蚀
与疾病组相比，伊维菌素组的炎症中等程度且显著减少
伊维菌素组的骨侵蚀、软骨侵蚀和类膜形成显著减少
结论：
“在我们的研究中，结果显示伊维菌素改善了与疾病组相比的组织病理学特征”
“使用伊维菌素的最终目的是保留组织结构、形态和功能。组织学数据表明，它在一定程度上成功保护了骨骼和关节，通过阻止炎症细胞的流入，以及关节腔内破骨细胞的分化和增殖。”
“我们的研究证明，伊维菌素确实具有抗炎和抗关节炎作用，在某些情况下与强效皮质类固醇地塞米松的效果相当。”（！！）
伊维菌素增加了体重，改善了视觉关节炎评分，并降低了白细胞、中性和淋巴细胞计数。
伊维菌素还降低了炎症细胞因子、TLR-2、TNF、IL-17和NF-κB的表达
现在你能明白为什么大制药公司如此害怕伊维菌素了😃
伊维菌素研究显示，其不仅对病毒具有令人印象深刻的活性，还对癌症和自身免疫疾病有效。
NEW ARTICLE: RESEARCH: IVERMECTIN in RHEUMATOID ARTHRITIS - 2023 Paper from Pakistan
What about Ivermectin and Rheumatoid Arthritis?
2023 Khan et al - Evaluation of therapeutic potential of ivermectin against complete Freund's adjuvant-induced arthritis in rats: Involvement of inflammatory mediators
HIGHLIGHTS:
32 male Wistar rats were randomly divided into four groups: control, diseased, dexamethasone, and ivermectin groups
After 7 days of rheumatoid arthritis induction, animals were treated with dexamethasone (steroid) 5 mg/kg and Ivermectin 6 mg/kg
RESULTS:
Ivermectin has no significant effect on the body weight of rats. Rat's body weight decreased in the diseased group.
On Day 15 of the study, there was a significant decrease in arthritis in the dexamethasone and ivermectin groups in comparison with the diseased group
there was significant increase in WBC count in the diseased group
After the treatment, the WBC count was significantly decreased in the dexamethasone and Ivermectin groups
There was highly significant subcutaneous inflammation, synovial inflammation, and bone erosion in the diseased group as compared with the control group
Inflammation in the Ivermectin group decreased moderately and significantly as compared with the diseased group
Bone erosion, cartilage erosion, pannus formation were decreased significantly in the Ivermectin group
CONCLUSION:
"In our study, results showed that ivermectin improved the histopathological characteristics in comparison with the diseased group"
"Ultimate aim of using ivermectin was to preserve the tissue architecture, morphology, and function. Histological data suggest that it has succeeded in protecting bone and joint articulation to some extent by preventing the influx of inflammatory cells, as well as the differentiation and proliferation of osteoclasts within the joint cavity."
"Our study has demonstrated that ivermectin does have anti-inflammatory and antiarthritic effects that are in some cases comparable with those of the potent corticosteroid dexamethasone." (!!)
Ivermectin increased body weight, improved the visual arthritic score, and decreased WBC, neutrophils, and lymphocytes counts.
Ivermectin also decreased the expression of inflammatory cytokines, TLR-2, TNF, IL-17, and NF-κB
Now you can see why Big Pharma fears Ivermectin so much 😃
Ivermectin research shows impressive Ivermectin activity not only against viruses, but also against cancer and autoimmune diseases.
